2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1902):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-152727
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(naphthalen-1-yl)purine
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(naphthalen-1-yl)purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(naphthalen-1-yl)purine
  • HY-154319
    1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine
    1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine
  • HY-B0158S2
    Cytidine-13C-1
    Cytidine-13C-1 is the 13C labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholami
    Cytidine-<sup>13</sup>C-1
  • HY-154564
    5’-Deoxy-5’-N-methylaminothymidine
    5’-Deoxy-5’-N-methylaminothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-Deoxy-5’-N-methylaminothymidine
  • HY-154571
    2’,3’,5’-Tri-O-acetyl-6-S-methyl-6-thio-guanosine
    2’,3’,5’-Tri-O-acetyl-6-S-methyl-6-thio-guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’,3’,5’-Tri-O-acetyl-6-S-methyl-6-thio-guanosine
  • HY-152680
    4-Amino-5-cyano-1- (β-D-ribofuranosyl)-7H-pyrrolo[2,3-d] pyrimidine
    4-Amino-5-cyano-1- (β-D-ribofuranosyl)-7H-pyrrolo[2,3-d] pyrimidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4-Amino-5-cyano-1- (β-D-ribofuranosyl)-7H-pyrrolo[2,3-d] pyrimidine
  • HY-90006S3
    5-Fluorouracil-13C4,15N2
    5-Fluorouracil-13C4,15N2 is the 13C and 15N labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
    5-Fluorouracil-<sup>13</sup>C<sub>4</sub>,<sup>15</sup>N<sub>2</sub>
  • HY-154611
    2’-Deoxy-2’-fluoro-5-methyl-4’-thio-a-D-arabino uridine
    2’-Deoxy-2’-fluoro-5-methyl-4’-thio-a-D-arabino uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluoro-5-methyl-4’-thio-a-D-arabino uridine
  • HY-154066
    3’-Deoxy-3’-flluoro-3-deazauridine
    3’-Deoxy-3’-flluoro-3-deazauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-3’-flluoro-3-deazauridine
  • HY-152451
    3’-Beta-C-ethynyl-N6-(m-methoxybenzyl)adenosine
    3’-Beta-C-ethynyl-N6-(m-methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). 3’-Beta-C-ethynyl-N6-(m-methoxybenzyl)adenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    3’-Beta-C-ethynyl-N6-(m-methoxybenzyl)adenosine
  • HY-152836
    2’-O-Methyl-5-hydroxymethyluridine
    2’-O-Methyl-5-hydroxymethyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-Methyl-5-hydroxymethyluridine
  • HY-152872
    Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester
    Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester
  • HY-154261
    Rev 2’-O-MOE-A(Bz)-5’-amidite
    Rev 2’-O-MOE-A(Bz)-5’-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Rev 2’-O-MOE-A(Bz)-5’-amidite
  • HY-138583
    Ac-dA Phosphoramidite
    Ac-dA Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides.
    Ac-dA Phosphoramidite
  • HY-152423
    3’-Deoxy-3’-α-C-methyl-N6,N6-dimethyladenosine
    3’-Deoxy-3’-α-C-methyl-N6,N6-dimethyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-3’-α-C-methyl-N6,N6-dimethyladenosine
  • HY-154289
    2’,3’-Isopropylidene-5-hydroxyuridine
    2’,3’-Isopropylidene-5-hydroxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’,3’-Isopropylidene-5-hydroxyuridine
  • HY-152709
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(5-phenylpyridin-3-yl)purine
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(5-phenylpyridin-3-yl)purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(5-phenylpyridin-3-yl)purine
  • HY-152771
    3′-Deoxy-3′-fluorocytidine
    3′-Deoxy-3′-fluorocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3′-Deoxy-3′-fluorocytidine
  • HY-152305
    (1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol
    (1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    (1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol
  • HY-W557556
    2',5'-Bis-O-(triphenylMethyl)uridine
    2',5'-Bis-O-(triphenylMethyl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    2',5'-Bis-O-(triphenylMethyl)uridine